The primary use of this medication is to treat both acute and chronic schizophrenia. It can also be used to treat bipolar disorder (mania).

IUPAC name: 2-(3-chlorobenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethylethanamine

Drug class: Atypical antipsychotics

Route of administration: Oral

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Is it a drug that needs a prescription? YES

Is it an OTC drug? NO

Mechanism of action

This medication works by regulating and restoring the activity of certain neurotransmitters (such as dopamine and serotonin) in the brain and helps to prevent delusions, hallucinations, and unusual thoughts.

Side effects

It may cause drowsiness, headache, constipation, indigestion, weight gain, vision problems, dry mouth, depression, anxiety, insomnia, difficulty urinating, loss of appetite, sweating, fainting, lack of energy, abnormal blood cell count.


Before using this medication, take the following precautions and notify your doctor:

If you are allergic to it or to other antipsychotic drugs (neuroleptic drugs), or if you have any other allergies,

If you are taking any other medication (prescribed, non-prescribed, or herbal products),

If you have a history of seizures, leukemia (low white blood cell count), intestinal blockage due to paralytic ileus, breathing/lung problems (including sleep apnea, severe asthma, COPD-chronic obstructive pulmonary disease), intestinal blockage due to paralytic ileus, diabetes, high cholesterol, glaucoma, cardiac disease (heart attack, congestive heart failure, hypertension), kidney problems, liver disease, obesity, acute gout,

If you have undergone any type of surgery,

Zotepine may increase the risk of QT prolongation if you have certain cardiac diseases (bradycardia, heart failure, or QT prolongation).


 If you have low blood levels of magnesium, potassium, or sodium, you may be more likely to experience QT prolongation (extended intervals between cardiac contraction and relaxation) when taking this medication.

Limit your alcohol usage since it increases your chances of developing blurred vision, dizziness, or drowsiness. It may also cause a loss of alertness.

This drug’s adverse effects are more severe in older adults with dementia.

Children under the age of 18 shouldn’t use it.

Avoid abruptly discontinuing this medication without first talking to your doctor.

If you are pregnant, talk to your doctor. Using this drug in the last trimester of pregnancy is not recommended since it might harm the unborn child.

This medication should not be taken by breastfeeding moms since it may pass via breast milk and harm the infant.

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