This medicine is prescribed to treat major depressive disorders. It can also be used off-label for the treatment of anxiety and insomnia associated with depression.

IUPAC name: 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one

Drug class: Atypical antidepressant; serotonin antagonist and reuptake inhibitors (SARI)

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Route of administration: Oral

Is it a drug that needs a prescription? YES

Is it an OTC drug? NO

Mechanism of action

This medication works by preventing serotonin uptake by brain nerves. More serotonin is released as a result, which stimulates additional neurons and helps the brain’s serotonin levels return to balance.

 Side effects

It may cause dizziness, fatigue, weakness, drowsiness, constipation, headache, nausea, vomiting, diarrhea, dry mouth, changes in weight, muscle pain, nervousness, nightmares, abdominal pain, fainting, sweating, itchy/tired eyes, decreased sexual desire, and slipping into a coma (loss of consciousness).


Before using this medication, take the following precautions and notify your doctor:

If you are allergic to it, or if you have other allergies, or if you are allergic to  other antidepressants such as MAO inhibitors,

If you are taking any other medication (prescribed, non-prescribed, or herbal products),

When you have a history of liver disease, kidney disease, and cardiac disease (QT syndrome, heart failure, cardiac arrest, heart attack), low sodium, potassium, or magnesium level in the blood, alcohol abuse, hypertension (high blood pressure),

Use of this medication may cause angle-closure glaucoma (a type of eye problem). Consult your doctor about eye examination.

If you have undergone any type of surgery,

Limit your alcohol usage since it increases your chances of developing blurred vision, dizziness, or drowsiness. It may also cause a loss of alertness.

This drug’s adverse effects are more severe in older adults.

This medication may affect your mental health.

Avoid abruptly discontinuing this medication without first seeing your doctor.

Consult your doctor if you are pregnant or breastfeeding.

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