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Thioridazine

Uses 

This drug is prescribed for the treatment of schizophrenia.

 IUPAC name: 10-[2-(1-methylpiperidin-2-yl)ethyl]-2-methylsulfanyl phenothiazine

Drug class: Typical antipsychotics; Phenothiazine

Route of administration: Oral

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Is it a drug that needs a prescription? YES

Is it an OTC drug? NO 

Mechanism of action

This medication works by inhibiting the activity of a neurotransmitter (dopamine) in the brain and helps to enhance thoughts, feelings, moods, and behavior.

Side effects

It may cause dizziness, drowsiness, postural hypotension, constipation, muscle cramps, dry mouth, restlessness, tremors, difficulty urinating, vision problems, and increased prolactin level.

Precautions

Before using this medication, take the following precautions and notify your doctor:

If you are allergic to it or to other antipsychotic (neuroleptic) drugs, or if you have any other allergies,

If you are taking any other medication (prescribed, non-prescribed, or herbal products),

If you have a history of hepatic disease, kidney problems, cardiac disease, hypotension (low blood pressure), glaucoma, seizures, intestinal blockage, lung/breathing problems, breast cancer, blood cell disorders ( anemia, leukemia, bone marrow depression, thrombocytopenia), pheochromocytoma, brain damage, dehydration, Parkinson’s disease, low blood calcium levels, drug or alcohol abuse, 

If you have undergone any type of surgery,

Since this drug increases your sensitivity to the sun, avoid spending time outside in the sun while taking it.

Limit your alcohol usage since it increases your chances of developing blurred vision, dizziness, or drowsiness. It may also cause a loss of alertness.

Thioridazine may increase the risk of QT prolongation if you have certain cardiac diseases (bradycardia, heart failure, or QT prolongation).

 If you have low blood levels of magnesium, potassium, or sodium, you may be more likely to experience QT prolongation (extended intervals between cardiac contraction and relaxation) when taking this medication.

This drug’s adverse effects are more severe in older adults with dementia.

Children are more likely to experience serious side effects with this medication.

Avoid abruptly discontinuing this medication without first talking to your doctor.

Avoid activities that can cause you to overheat while taking this medication.

If you are pregnant, talk to your doctor. Using this drug in the last trimester of pregnancy is not recommended since it might harm the unborn child.

Consult your doctor if you are breastfeeding.

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