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Rucaparib

Uses

This anti-cancer medication is used for the following conditions:

  • Advanced epithelial ovarian cancer
  • Cancer of the fallopian tube
  • Cancer of the peritoneum

This drug is typically used when a patient has already had chemotherapy treatments.

IUPAC name: 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide

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Drug class: Antineoplastic; PARP (poly ADP ribose polymerase) inhibitor

Route of administration: Oral

Is it a drug that needs a prescription? YES

Is it an OTC drug? NO

Mechanism of action

Rucaparib works by inhibiting the activity of the PARP enzyme, which plays a crucial role in restoring damaged DNA in cancerous cells. This results in the death of cancerous cells and tumor growth has been prevented.

Side effects

Common side effects may include nausea, vomiting, constipation, bad mouth taste, dizziness, loss of appetite, sore throat, back pain, insomnia, headache

Serious side effects

Yellowing of skin/eyes, tingling/blisters of the hands and feet, unusual fatigue, shortness of breath, bruising/bleeding easily, weight loss, blood in urine or stool

Precautions

Take the following precautions before using this drug and notify your doctor:

  • If you are allergic to it or if you have any other allergies,
  • If you are taking any other medications (prescribed, non-prescribed, or herbal products),
  • If you have medical history of cardiac disease, hypertension, hepatic or renal disease,

This drug should not be used when pregnant or breastfeeding.

To avoid becoming pregnant while using this medicine, use an effective form of birth control.

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