Propylthiouracil for Hyperthyroidism


The drug is prescribed for the treatment of hyperthyroidism (overactive thyroid) and Graves’ disease (toxic goitre).

 IUPAC name: 6-propyl-2-sulfanylidene-1H-pyrimidin-4-one

Drug Class: Thyroid Hormone Synthesis Inhibitor

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Route of administration: Oral 

This drug is a prescribed drug and not an OTC drug 

Drug action mechanism 

This medication prevents the thyroid gland from producing an excessive amount of thyroxine hormone.

 Adverse effects

The adverse effects of propylthiouracil may include nausea, vomiting, stomach/abdominal pain, dizziness, pain in muscles or joints, rash/itching, sore throat, swelling, and difficulty breathing. 


If the person experiences signs of hepatic illness such as nausea and vomiting that won’t stop, intense stomach/abdominal pain, dark urine, or yellowing of the skin or eyes, stop taking propylthiouracil and notify a physician once.


It is advisable to consult a doctor or physician before taking this medication. 

  • Avoid the usage of this medication, if the patient is allergic to this drug, or has any other allergies if the patient is on any other medication (i.e., prescribed, non-prescribed or usage of any herbal products) if the patient suffers from a hepatic disease, renal issues, thyroid disorder i.e., hypothyroidism 
  • While taking this drug, avoid alcohol consumption as it leads to liver damage. Avoid the usage of this medication, if the patient has undergone any type of surgery i.e., dental or eye surgery. This medication has adverse effects on old people
  • This medication can be used only in the first three months of the pregnancy. It is not recommended in the later six months of pregnancy. Consult the doctor if the person is breastfeeding and Propylthiouracil is not recommended for children without doctors’ advice. 

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