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Pimozide

Uses

This medication is used to minimize motor and vocal tics in Tourette’s syndrome patients. Only severe tics that prevent an individual from engaging in everyday activities should be treated with it.

IUPAC name: 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1H-benzimidazol-2-one

Drug class: Typical antipsychotics

Route of administration: Oral

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Is it a drug that needs a prescription? YES

Is it an OTC drug? NO 

Mechanism of action

This medication works by inhibiting the activity of a neurotransmitter (dopamine) in the brain and helps to enhance thoughts, feelings, and moods.

Side effects

It may cause dizziness, drowsiness, dry mouth, headache, vision problems, weight gain, constipation, fatigue, muscle cramps, salivation, and restlessness.

Precautions

Before using this medication, take the following precautions and notify your doctor:

If you are allergic to it or to other antipsychotic (neuroleptic) drugs, or if you have any other allergies,

If you are taking any other medication (prescribed, non-prescribed, or herbal products),

If you have a history of cardiac disease (arrhythmia, heart attack, heart failure), blood disorders (anemia, leukemia, thrombocytopenia), glaucoma, depression, low blood pressure, liver disease, kidney disease, dementia, Parkinson’s disease, dementia, seizures, breast cancer, drug or alcohol abuse,

If you have undergone any type of surgery,

Pimozide may increase the risk of QT prolongation if you have certain cardiac diseases (bradycardia, heart failure, or QT prolongation).

If you have low blood levels of magnesium, potassium, or sodium, you may be more likely to experience QT prolongation (extended intervals between cardiac contraction and relaxation) when taking this medication.

Limit your alcohol usage since it increases your chances of developing blurred vision, dizziness, or drowsiness. It may also cause a loss of alertness.

This drug’s adverse effects are more severe in older adults with dementia.

Children are more likely to experience serious side effects with this medication.

If you are pregnant, talk to your doctor. Using this drug in the last trimester of pregnancy is not recommended since it might harm the unborn child. 

Consult your doctor if you are breastfeeding.

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