This medication is prescribed to treat schizophrenia.

Additionally, it is used to treat severe vomiting, and nausea. 

IUPAC name: 2-[4-[3-(2-chloro phenothiazine-10-yl)propyl]piperazin-1-yl]ethanol

Drug class: Typical antipsychotics

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Route of administration: Oral

Is it a drug that needs a prescription? YES

Is it an OTC drug? NO 

Mechanism of action

Both an antipsychotic and an antiemetic effect are produced by this drug. Dopamine, one of the brain’s neurotransmitters, is inhibited as it works to improve thoughts, feelings, moods, and behavior.

Side effects

It may cause dizziness, dry mouth, drowsiness, constipation, vision problems, weight gain, headache, fatigue, loss of appetite, salivation, nausea, involuntary muscle contraction, tremors, and uncontrollable facial movements.


Before using this medication, take the following precautions and notify your doctor:

If you are allergic to it or to other antipsychotic (neuroleptic) drugs, or if you have any other allergies,

If you are taking any other medication (prescribed, non-prescribed, or herbal products), 

If you have a history of cardiac diseases (arrhythmia, angina, heart attack, heart valve problems), bone marrow depression, hepatic issues, Parkinson’s disease, seizures, restless legs syndrome, hypotension (low blood pressure), breast cancer, lung/breathing disease, pheochromocytoma, prostate gland problems, drug or alcohol abuse.

If you have undergone any type of surgery,

Perphenazine may increase the risk of QT prolongation if you have certain cardiac diseases (bradycardia, heart failure, or QT prolongation).

 If you have low blood levels of magnesium, potassium, or sodium, you may be more likely to experience QT prolongation (extended intervals between cardiac contraction and relaxation) when taking this medication. 

Since this drug increases your sensitivity to the sun, avoid spending time outside in the sun while taking it.

Limit your alcohol usage since it increases your chances of developing blurred vision, dizziness, or drowsiness. It may also cause a loss of alertness.

This drug’s adverse effects are more severe in older adults with dementia.

Children are more likely to experience serious side effects with this medication. 

Avoid activities that can cause you to overheat while taking this medication.

If you are pregnant, talk to your doctor. Using this drug in the last trimester of pregnancy is not recommended since it might harm the unborn child.

Consult your doctor if you are breastfeeding.

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