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Osimertinib

Uses

This drug is used to treat non-small cell lung cancer in people who have specific EGFR mutations.

 IUPAC name: N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindole-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide

Drug class: Antineoplastic; EGFR tyrosine kinase inhibitor

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Route of administration: Oral

Is it a drug that needs a prescription? YES

Is it an OTC drug? NO 

Mechanism of action

Osimertinib functions as an EGFR tyrosine kinase inhibitor, decreasing or inhibiting cancer cell growth and proliferation by inhibiting aberrant EGFR signaling pathways. 

Side effects

Diarrhea, nausea, vomiting, dry skin, loss of appetite, taste changes, rash, itching, stomatitis, changes in nails, exhaustion, blistering of skin, trouble breathing, changes in eyesight, dizziness, fainting, and chest discomfort are all possible adverse effects of osimertinib.

Precautions

Before using this medication, take the following precautions and notify your doctor:

  • If you are allergic to it or have any other allergies,
  • If you are taking any other medication (prescribed, non-prescribed, or herbal products),
  • If you have a medical history of abnormally fast heart rate (QT prolongation), cardiac disease, low levels of potassium, calcium, sodium, or magnesium, vision problems,
  • Limit your alcohol consumption.
  • It may affect fertility in men and women.
  • You should not get pregnant while taking this medication.
  • This medication is not recommended during pregnancy.
  • Breastfeeding should be avoided while the treatment is going on and for the next 2 weeks after stopping the use of this drug.

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