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Nilotinib

Uses

This anticancer drug is used for the treatment of Philadelphia Chromosome positive chronic myeloid leukemia (a type of blood cancer).

IUPAC name: 4-methyl-N-[3-(4-methyl imidazol-1-yl)-5-(trifluoromethyl) phenyl]-3-[(4-pyridin-3-yl pyrimidin-2-yl)amino] benzamide

Drug class: Antineoplastic; Kinase inhibitor

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Route of administration: Oral

Is it a drug that needs a prescription? YES

Is it an OTC drug? NO

Mechanism of action

Nilotinib is a tyrosine kinase inhibitor that inhibits cancerous cell development and proliferation by blocking the action of an aberrant protein that signals cancer cells to multiply.

Side effects

Nausea, vomiting, dry skin, diarrhea, decreased appetite, headache, constipation, sore mouth, weakness, dizziness, rash, itching, weight gain, hair loss, numbness/tingling of the hands or feet, pain in muscles or joints, trouble sleeping.

Precautions

Before using this medication, take the following precautions and notify your doctor:

  • If you are allergic to it or have any other allergies,
  • If you are taking any other medication (prescribed, non-prescribed, or herbal products),
  • If you have a medical history of heart problems (including heart attacks, coronary artery disease), hypertension (high blood pressure), atherosclerosis, blood circulation disease, diabetes, high levels of cholesterol, low levels of magnesium and potassium,
  • It may cause abnormal heart rhythm (QT prolongation).
  • If you have had stomach surgery,
  • Older adults and children are more sensitive to the adverse effects of this medication.
  • Consult your doctor if you are pregnant or intend to become pregnant.
  • This medication should not be given during pregnancy as it may harm the baby.
  • You should avoid breastfeeding while the treatment is going on and 2 weeks after the treatment.

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