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Neratinib

Uses

This anticancer drug is used for the treatment of advanced or metastatic HER2 positive breast cancer.

IUPAC name: (E)-N-[4-[3-chloro-4-(pyridin-2-yl methoxy)anilino]-3-cyano-7-methyl quinolin-6-yl]-4-(dimethylamino)but-2-enamide

Drug class: Antineoplastic; Kinase inhibitor

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Route of administration: Oral

Is it a drug that needs a prescription? YES

Is it an OTC drug? NO

Mechanism of action

Neratinib is a tyrosine kinase inhibitor that works as a targeted cancer treatment. It acts by suppressing the action of a protein called human epidermal growth factor receptor 2 (HER2), which suppresses cancer cell growth and proliferation.

Side effects

Stomach pain, nausea, vomiting, dry skin/mouth, loss of appetite, fatigue, muscle spasms, weight loss, changes in nails, diarrhea, dizziness, rapid heartbeats, dehydration, dark urine, rash/itching, swelling of mouth/face/throat, trouble breathing.

Precautions

Before using this medication, take the following precautions and notify your doctor:

  • If you are allergic to it or have any other allergies,
  • If you are taking any other medication (prescribed, non-prescribed, or herbal products),
  • If you have a medical history of hepatic disease, indigestion, ulcers, heartburn,
  • Consult your doctor if you are pregnant or intend to become pregnant.
  • This medication should not be given during pregnancy.
  • You should avoid breastfeeding while the treatment is going on and for the next 4 weeks after the treatment.

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