Isosorbide Dinitrate, a Nitrate Vasodilator


The drug is prescribed to prevent angina (decreased cardiac blood flow causing chest discomfort).

IUPAC Name: [(3S,3aS,6R,6aS)-3-nitrooxy-2,3,3a,5,6,6a-hexahydro furo [3,2-b] furan-6-yl] nitrate

Drug Class: Nitrate Vasodilator

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Route of administration: Sublingual

This is a prescribed drug and not an OTC Drug 

Drug Action Mechanism

 It functions by relaxing or widening the blood vessels, which lowers the heart’s need for oxygen and lessens the burden on the heart, avoiding angina (heart-related chest discomfort).  

Side Effects

It could result in lightheadedness, dizziness, nausea, headache, flushing, vision problems, and palpitations.


Before using this medication, take the following precautions and notify the doctor:

  • If the person is allergic to the drug or other nitrates, or if the person has other allergies,
  • If the person is taking any other medication (prescribed, non-prescribed, or herbal products),
  • If the person has or ever had a heart attack or other cardiac disease (such as congestive heart failanaemiaanemia (low red blood cells), hypotension (low blood pressure), abnormally fast heart rate, head injury, dehydration, stomach cramps,
  • If the person has undergone any type of surgery i.e., eye or ear surgery, 
  • While taking this medication, limit alcohol usage since it increases the chances of developing blurred vision, dizziness, or drowsiness. It may also cause a loss of alertness.
  • Avoid abruptly discontinuing this medication without consulting a doctor.
  • The adverse effects of this medication may affect elder people more severely.
  • Consult a doctor if the person is pregnant or breastfeeding.

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