This medication is used to treat underlying conditions:

-vaginal atrophy/urethral atrophy after menopause due to low level of estrogen

-vaginal dryness/itching/burning/inflammation

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 -vulva tissue degeneration

– painful intercourse

IUPAC name:  (17β)-estra-1,3,5(10)-triene-3,17-diol

Drug class: Estrogen derivative

Product type: Estradiol cream

Is it a drug that needs a prescription? YES

Is it an OTC drug? NO

Mechanism of action

It functions similarly to the female hormone estrogen. It binds to the estrogen receptor and works by calming the vasomotor system (such as hot flashes) and urogenital symptoms (including vaginal dryness).

Side effects

Common side effects may include nausea, vomiting, breast tenderness/pain, weight gain/loss, headache.

Serious side effects may include depressed mood, spotting (vaginal bleeding), unusual vaginal discharge, severe abdominal pain.


 Following precautions should be taken before using this medication and notify your doctor:

  1. If you are allergic to this medication, or any other medications or if you have any other kind of allergies.
  2. If you have or ever had a medical history of  untreated vaginal bleeding, cancer of the uterus, ovaries and breast, blood clots, kidney disease, heart attack, liver disease, strokes, migraine, high blood pressure (hypertension), seizures, protein C deficiency disease, depression, obesity, asthma, diabetes, high cholesterol level, hypothyroidism, high/low level of calcium in blood, endometriosis, uterine fibroids, depression.
  3. Avoid use of tobacco and smoking. It will increase the risk of blood clots, high blood pressure, stroke/ heart attacks.
  4. If you are taking any other medication (including prescription drugs, nonprescription drugs and herbal products).
  5. It may cause melasma, avoid going out in sunlight as it may worsen the effect.
  6. This medication should not be used during pregnancy.

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