It is employed in the treatment of endometrial cancer (cancer of the uterine lining). It is also used to treat solid tumors.

Drug class: Monoclonal antibodies

Route of administration: Intravenous

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Is it a drug that needs a prescription? YES

Is it an OTC drug? NO

Mechanism of action

Dostarlimab is an immunotherapy drug. It works by blocking the PD-1 receptor on T cells, preventing interaction with PD-L1 and PD-L2. This activates the PD-1 pathway, which suppresses the anti-tumor immune response, allowing cancerous cells to be eradicated. 

Side effects

Common side effects may include nausea, tiredness, muscle pain.

 Some of the more serious side effects include: diarrhea, abdominal pain, sore throat, pale skin, change in urine amount/color, easy bleeding/bruising, weight changes, eyesight changes, unusual disorientation, loss of balance, joint stiffness, and muscle cramps.


Take the following precautions before using this drug and notify your doctor:

If you are allergic to it or if you have any other allergies,

If you are taking any other medications (prescribed, non-prescribed, or herbal products),

If you have a medical history of organ transplant, bone marrow transplant, autoimmune disease, ulcerative colitis, myasthenia gravis, thyroid problem, hepatic disease, lung problem,

In rare cases, you’ll be diagnosed with endometrial cancer when you are pregnant or breastfeeding. In such cases, this medication is not used.

 Do not get pregnant while using this medicine, use an effective form of birth control.

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