This medication is used to treat the following underlying conditions:

-atrophic vaginitis due to low level of estrogen

-urethral atrophy after menopause

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-vulva tissue degeneration

-painful intercourse

IUPAC name: 4-[(2E,4E)-4-(4-hydroxyphenyl)hexa-2,4-dien-3-yl]phenol

Drug class: Non-steroidal estrogen

Is it a drug that needs a prescription? YES

Is it an Over The Counter drug? NO

Product type: Vaginal topical cream

Mechanism of action

Dienestrol is estrogen, a female hormone. It is applied to the vaginal cavity to help alleviate menopausal symptoms including vaginal inflammation or dryness, as well as painful intercourse.

Side effects

 Side effects may include nausea, bloating, dizziness, upset stomach, breast tenderness, irritation in vagina, headache, unusual vaginal discharge, weight gain/loss.


This medication should not be used in patients who have undiagnosed vaginal/uterine bleeding, hormone-dependent breast cancer, pregnancy, or blood clot problems.


Take the following precautions before using this medication and notify your doctor.

  • If you have a history of kidney disease, asthma, heart problems, migraine, rash/itching, or hives, consult your doctor.
  • Limit your alcohol consumption because it causes drowsiness and a loss of alertness.
  • Melasma may develop as a result. Avoid going out in direct sunlight as this may exacerbate the effect.
  • This medication should be avoided during pregnancy because it has the potential to harm the unborn child.

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