The following underlying conditions are treated with denosumab:

  • Osteoporosis in women after menopause
  • Osteoporosis in men
  • Osteoporosis due to corticosteroids
  • Risk of bone fractures (broken bones)

Drug class: Monoclonal antibodies

Route of administration: Subcutaneous

Is it a drug that needs a prescription? YES

Is it an OTC drug? NO

Mechanism of action

Denosumab works by targeting RANKL and inhibiting the activity of osteoclasts (bone resorption) and supporting osteoblasts in bone formation. As a result, it facilitates in the prevention of bone density loss.

Adverse effects

Common side effects may include muscle cramps, stiffness, spasms, severe dizziness, and abdominal pain. 

Serious side effects may include numbness around the mouth or tingling in fingers/toes, trouble breathing, painful/burning urination, swollen gums, and jaw pain.


Before using this medication, take the following precautions and notify your doctor:

  • If you are allergic to it or if you have any other allergies,
  • If you have a medical history of hypocalcemia (low level of calcium in the blood), thyroid/parathyroid problems, or stomach problems,
  • If you have jaw pain,
  • This medication is not recommended during pregnancy.

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