This medication is used to manage high blood sugar levels (hyperglycemia) in individuals with type 2 diabetes (the body either produces insufficient insulin or rejects insulin), ideally in combination with a balanced lifestyle (appropriate food and exercise) and other medications.

IUPAC name: 1-(4-chlorophenyl) sulfonyl-3-propylurea

Drug class: Anti-diabetic drug; sulfonylureas

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Route of administration: Oral

Is it a drug that needs a prescription? YES

Is it an OTC drug? NO

Mechanism of action

Chlorpropamide works by activating pancreatic beta cells to produce insulin, which helps in the reduction of blood sugar or glucose levels in patients with type 2 diabetes.

Side effects

Chlorpropamide may cause nausea, vomiting, diarrhea, dizziness, anxiety, shakiness, stomach/abdominal discomfort, weight gain, constipation, headache, sore throat, fever, easy bleeding or bruising, yellowing of skin or eyes, dark urine, fatigue, hypoglycemia (low blood sugar level). 


Before using this medication, take the following precautions and notify your doctor:

If you are allergic to it or have any other allergies,

If you are taking any other medication (prescribed, non-prescribed, or herbal products),

If you have a history of hepatic, or renal illness, a low sodium level in your blood, certain hormone abnormalities (such as thyroid gland problems or pituitary/adrenal gland disease), hemolytic anemia, or a combination of these conditions,

If you have undergone any type of surgery,

Limit your alcohol usage since it increases your chances of obtaining low blood sugar levels. It may also cause headaches, vomiting, nausea, flushing, disorientation, and anxiety.

You may have dizziness, changes in vision, or lack of awareness as a result of low or high blood sugar levels.

When your body is stressed, controlling your blood glucose level becomes challenging.

Avoid going out in the sun since this medication makes your skin sun-sensitive.

Consult your doctor if you get pregnant or if you are breastfeeding while using this medication.

This drug is not advised to be taken while pregnant.

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