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Bupropion

Uses

This medication is used to treat depression and seasonal affective disorder (SAD), as well as to help in the cessation of smoking.

IUPAC name: 2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-one

Drug class: Atypical antidepressant; norepinephrine/dopamine-reuptake inhibitor (NRDI)

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Route of administration: Oral

Is it a drug that needs a prescription? YES

Is it an OTC drug? NO

Mechanism of action

This drug inhibits norepinephrine and dopamine neuronal reuptake in the brain. As a result, norepinephrine and dopamine levels rise, activating more neurons and helping in the restoration and maintenance of mental stability.

It also works as a nicotinic receptor antagonist, inhibiting the receptors where nicotine typically attaches and assisting in the cessation of smoking.

 Side effects

It may cause nausea, headache, drowsiness, dry mouth, insomnia, weight loss, constipation, loss of appetite, dizziness, blurred vision, sweating, sore throat, taste changes, stomach pain, fast heart rate.

Precautions

Before using this medication, take the following precautions and notify your doctor:

If you are allergic to it, or if you have other allergies, or if you are allergic to other antidepressants,

If you are taking any other medication (prescribed, non-prescribed, or herbal products),

If you have a history of brain tumor, head injury, seizures, cardiac disease (heart attack, congestive heart failure), hepatic disease (cirrhosis), kidney problems, high blood pressure (hypertension), diabetes, eating disorders (including anorexia nervosa, bulimia nervosa), bipolar disorder/manic depression, angle closure glaucoma, or a family history of suicidal thoughts,

Use of this medication may cause angle-closure glaucoma (a type of eye problem). Consult your doctor about an eye exam.

If you have undergone any type of surgery,

Limit your alcohol usage since it increases your chances of developing blurred vision, dizziness, or drowsiness. It may also cause a loss of alertness.

This drug’s adverse effects are more severe in older adults.

Avoid abruptly discontinuing this medication without first seeing your doctor.

Consult your doctor if you are pregnant or breastfeeding.

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