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Alendronate

USES:
The following underlying conditions are treated with alendronate:

  1. Osteoporosis in women after menopause.
  2. Paget’s disease of bone
  3. Osteoporosis as a result of corticosteroid use for an extended period of time
  4. Osteoporosis in men

IUPAC name: (4-amino-1-hydroxy-1-phosphonobutyl)-hydroxyphosphinate
Drug class: Bisphosphonates
Route of administration: Oral

Is it a drug that needs a prescription? YES

Is it an OTC drug? NO

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Mechanism of action
Alendronate works by inhibiting the activity of osteoclasts (bone resorption). As a result, it facilitates the prevention of bone density loss and lessens the risk of bone fractures.

Side effects

Common side effects may include nausea, stomach pain, diarrhea, constipation, bloating, headache, dizziness.

Serious side effects may include swelling of joints/hands/legs/ankles, severe pain in joints/bone/muscle, black, tarry stools, pain in chest, vomiting, heartburn, unusual pain in groin/thighs/hips, ulcers in esophagus, rash/itching/hives.

Precautions
Before using this medication, take the following precautions and notify your doctor:
If you are allergic to bisphosphonates or any other allergens.
If you have a history of achalasia (esophageal disorder), difficulty swallowing, low calcium levels, kidney disease, or ulcers.
If you can’t sit or stand straight for at least 30 minutes.
If you have a jawbone problem or pain.
If you are pregnant or nursing.
Keep out of the reach of children.

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