Abaloparatide is used for the treatment of bone loss i.e. osteoporosis in postmenopausal women who are at risk of bone fracture (broken bones).
IUPAC name: L-alanyl-L-valyl-L-seryl-L-alpha-glutamyl-L-histidyl-L-glutaminyl-L-leucyl-L-leucyl-L-histidyl-L-alpha-aspartyl-L-lysyl-glycyl-L-lysyl-L-seryl-L-isoleucyl-L-glutaminyl-L-alpha-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-arginyl-L-alpha-glutamyl-L-leucyl-L-leucyl-L-alpha-glutamyl-L-lysyl-L-leucyl-L-leucyl-alpha-methyl-alanyl-L-lysyl-L-leucyl-L-histidyl-L-threonyl-L-alaninamide
Drug class: parathyroid hormone-related protein (PTHrP) analog; osteoanabolic drugs
Route of administration: Subcutaneous
Is it a drug that needs a prescription? YES
Is it an OTC drug? NO
Mechanism of action
Abaloparatide acts by stimulating the formation of bone since it is an analog of human parathyroid hormone-related protein which binds to type1 PTH receptors resulting in longer cAMP signaling.
Common side effects may include:
- Redness/swelling at the site of injection
- Increased heart rate
Take the following precautions before using this medication and notify your doctor:
- If you are allergic to it or if you are allergic to anything else.
- If you have a medical history of Paget’s disease, bone cancer, hypercalcemia, kidney problems, or a high parathyroid hormone level.
- Limit your alcohol consumption, as it makes you more drowsy and loss of alertness may occur.
- This medication is not advised to be taken while pregnant or nursing.