Abaloparatide is used for the treatment of bone loss i.e. osteoporosis in postmenopausal women who are at risk of bone fracture (broken bones).

IUPAC name: L-alanyl-L-valyl-L-seryl-L-alpha-glutamyl-L-histidyl-L-glutaminyl-L-leucyl-L-leucyl-L-histidyl-L-alpha-aspartyl-L-lysyl-glycyl-L-lysyl-L-seryl-L-isoleucyl-L-glutaminyl-L-alpha-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-arginyl-L-alpha-glutamyl-L-leucyl-L-leucyl-L-alpha-glutamyl-L-lysyl-L-leucyl-L-leucyl-alpha-methyl-alanyl-L-lysyl-L-leucyl-L-histidyl-L-threonyl-L-alaninamide

Drug class: parathyroid hormone-related protein (PTHrP) analog; osteoanabolic drugs

Route of administration: Subcutaneous
Is it a drug that needs a prescription? YES
Is it an OTC drug? NO

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Mechanism of action
Abaloparatide acts by stimulating the formation of bone since it is an analog of human parathyroid hormone-related protein which binds to type1 PTH receptors resulting in longer cAMP signaling.

Side effects

Common side effects may include:

  • Dizziness
  • Lightheadedness
  • Redness/swelling at the site of injection
  • Nausea
  • Tiredness/fatigue
  • Increased heart rate
  • Hypercalcemia


Take the following precautions before using this medication and notify your doctor:

  • If you are allergic to it or if you are allergic to anything else.
  • If you have a medical history of Paget’s disease, bone cancer, hypercalcemia, kidney problems, or a high parathyroid hormone level.
  • Limit your alcohol consumption, as it makes you more drowsy and loss of alertness may occur.
  • This medication is not advised to be taken while pregnant or nursing.

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